Background

Epidemiological evidence has suggested a link between beta-agonists and increases in asthma mortality. There has been much debate about possible causal links for this association, and whether regular (daily) long-acting beta2-agonists are safe.

Objectives

Objective To describe the attitudes and behaviours regarding placebo treatments, defined as a treatment whose benefits derive from positive patient expectations and not from the physiological mechanism of the treatment itself.

Design Cross sectional mailed survey.

Setting Physicians’ clinical practices.

Participants 1200 practising internists and rheumatologists in the United States.

Background: Evidence comparing premixed insulin analogues (a mixture of rapid-acting and intermediate-acting insulin analogues) with other antidiabetic agents is urgently required to guide appropriate therapy.

Purpose: To summarize the English-language literature on the effectiveness and safety of premixed insulin analogues compared with other antidiabetic agents in adults with type 2 diabetes.

تعتبر حاصرات البيتا أحد أنواع الأدوية التي تستخدم على نطاق واسع لعلاج ارتفاع ضغط الدم وربما تؤدي إلى مشاكل في القلب.

وتعمل حاصرات البيتا على خفض معدل ضربات القلب مما يقلل من ضغط الدم . وقد اتضح أن خفض معدل ضربات القلب بحاصرات البيتا له آثار مفيدة للأشخاص الذين يعانون من نوبة قلبية أو فشل في القلب .

اجرى عدد من الباحثين دراسة علمية تهدف إلى تحديد ما إذا كان إحلال الأنسولين مبكرا" يخفض زيادة السكر في الدم و يؤثر في النتائج للمواليد الجدد، وقد تضمنت الدراسات البالغين والأطفال الذين تم علاجهم في وحدات العناية المركزة و تشير الدراسات إلى أن العلاج بالأنسولين والسيطرة على مستوى الجلوكوز قد تؤثر على البقاء.
كما أن زيادة السكر في الدم ل لأطفال حديثي الولادة ناقصي الوزن هي أيضا مرتبطة بمعدلات المرض والوفاة.

Background: Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary arterial hypertension.

Objective: To investigate the effect of adding oral sildenafil to long-term intravenous epoprostenol in patients with pulmonary arterial hypertension.

Design: A 16-week, double-blind, placebo-controlled, parallel-group study.

 Postdischarge use of evidence-based drug therapies has been proposed as a measure of quality of care for myocardial infarction patients. We examined trends in the use of evidence-based drug therapies after discharge among elderly patients with myocardial infarction.

FDA appreciate the hard work and long hours the subcommittee has invested in scientific peer review of the FDA’s draft safety assessment of the use of BPA in food contact applications. The FDA requested this peer review to provide additional insight into this complex issue. This group of distinguished scientists has devoted their considerable knowledge and experience to this effort.

Context Folate, vitamin B6, and vitamin B12 are thought to play an important role in cancer prevention.

Objective To evaluate the effect of combined folic acid, vitamin B6, and vitamin B12 treatment on cancer risk in women at high risk for cardiovascular disease.