Safety information about:

contraindication in pregnant women and in women of childbearing potential not using effective contraception

Communication on progressive multifocal leukoencephalopathy (PML) 

Hemophagocytic syndrome (HPS)

Cardiovascular Adverse Events after the First Dose

Slow heart rate and irregular heartbeat.

Instructions for proper use

DHPC: Updated recommendations to minimize the risk of drug-induced liver injury